With other anti-cancer agents across several tumor types. generic viagra online Dr. Richardson, along with dr. Ken anderson at dfci and other leading investigators from mm centers including emory university, university of michigan, alta bates, city of hope, university of virginia and northwestern university have been instrumental in the pre-clinical and clinical development of perifosine for mm. best online viagra reviews The poster (abstract # 3582), entitled "a multicenter phase ii study of perifosine (krx-0401) alone and in combination with dexamethasone (dex) for patients with relapsed or relapsed/refractory multiple myeloma (mm)," was presented today, december 11th, 2006 at 10:30 am in the orange county convention center. In this ongoing phase ii study, patients with relapsed or relapsed/refractory multiple myeloma are treated with krx-0401 (150 mg oral daily dose) to assess the single agent activity of krx-0401 in this patient population. If a patient progresses on krx-0401 alone, dexamethasone (20mg twice weekly) is added to their krx-0401 regimen. Results: 55 patients (30 men and 25 women, median age 63 y, range 3879) have been treated to date. All had relapsed and refractory mm, with a median of 4 lines of prior treatment (range 2 - 11). order viagra Prior therapy included dex (95%), thalidomide (89%), bortezomib (78%), lenalidomide (31%) and stem cell transplant (73%). viagra generic Among 33 patients currently evaluable for response, best response (ebmt/blade criteria) to single agent perifosine after 2 cycles was stable disease (<25% reduction in m-protein) in 13 patients (39%). buy viagra Dex was added in 30 of 55 patients with pd, with 23 patients evaluable for response on the combination, reported as follows: perifosine dex n (%) duration (wks) pr 2 (9%) 13 , 17 mr 4 (17%) 4, 16 , 28 , 30 stable disease 11 (48%) 6 - 20 (median 18)* *4 pts ongoing at 16, 18, 20 and 20 weeks the most common grade 3/4 adverse events were nausea (7%); vomiting (4%); diarrhea (2%); fatigue (2%), and increased creatinine (8% in the context of pd and light chain nephropathy). viagra pills Dose reduction (150 to c or 50 mg/d) was required in 16 patients and 7 patients discontinued treatment due to adverse events. Attributable toxicities otherwise proved manageable with appropriate supportive care. cheap viagra online Perifosine was generally well tolerated, with no peripheral neuropathy or dvt seen. The conclusion of the investigators is that perifosine alone or in comb. viagra over the counter northern ireland viagra uk wiki
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